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DAILYKENN.com -- The positive effect of calorie restriction on aging is nothing new.
What is new is how and why it works on a cellular level.
“'We already knew that calorie restriction increases life span, but now we’ve shown all the changes that occur at a single-cell level to cause that,' says Juan Carlos Izpisua Belmonte" [salk.edu].
The study compared rats who ate 30 percent fewer calories with rats on normal diets.
Researchers compared cells from young to old rats.
"[E]ven in old age, many of the tissues and cells of animals on the diet closely resembled those of young rats," the report said.
Can calorie restriction reverse aging? Apparently so.
"[I]n brown adipose tissue—one type of fat tissue—a calorie-restricted diet reverted the expression levels of many anti-inflammatory genes to those seen in young animals, the reported added."
It seems there is a "master switch" that affects a broad range of cells.
It's a transcription factor called Ybx1.
By altering the transcription factor, calorie restriction seems to enhance "the expression levels of many anti-inflammatory genes to those seen in young animals."
