In this video we will discuss an article published in the New England Journal of Medicine where a genome wide analysis was done on almost 2,000 patients with severe COVID-19 with respiratory failure as compared to over 2,000 control patients. They found two different genetic loci with variants that appeared to be associated with severe respiratory disease in COVID-19. The first encoded genes involved in the ACE2 and CD8 T cell responses in lung tissue. Interesting, the second loci encoded for ABO blood types finding blood group O had a lower risk for severe disease. We will discuss what these are and why they may have a protective effect! Why this may be? Check out the video for all the details!
PLAYLIST ON COVID-19 PATHOPHYSIOLOGY:
https://youtube.com/playlist?list=PLf5bMa9_tvRiAsl2GNnLYM1zJZ8GNG_W_
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Link to article: https://www.nejm.org/doi/full/10.1056/NEJMoa2020283
There will be a running series of videos using the most up to date information on COVID-19, but this is an evolving field and new videos may come out that contradict that previous information. That is okay and is the nature of a fast paced and evolving clinical scenario. Stick with us as we work to unveil the intricacies of COVID-19, it's clinical significance, and the societal implications. *****This is strictly educational and not to be mistaken as clinical recommendations, please verify all information with accepted guidelines and practice patterns.****
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