Decreased Mortality And Hospitalization In Early Outpatient COVID-19: Colchicine + COLCORONA Trial!

   

Whiteboard Doctor

 

Published on Jan 25, 2021

A brand new massive randomized control trial has been completed on the treatment of early, outpatient COVID-19 in those high risk for decompensation using a cheap, widely available drug named Colchicine! They found really astounding results including a decreased rate of hospitalization by 25%, decreased mortality by 44%, and decreased ventilation needs by 50%! In this video, we discuss the trial design, inclusion/exclusion criteria, and number of participants. We dive into the results they have made public as we wait for the publication of the full data set. We illustrate how Colchicine works including several immuno-modulating, anti-inflammatory, and anti-oxidant mechanisms. We describe the dosing, contraindications, and possibility of toxicity. Lastly, we highlight a few countries that have already approved Colchicine for COVID-19! Check out the video for all these details and more!

Playlist On Additional Therapies And COVID-19 (Plasma, Tocilizumab, Aviptadil, Colchicine)
https://youtube.com/playlist?list=PLf5bMa9_tvRiJeHPIMjC42NpLYHAYgQba

PREVIOUS VIDEOS ON COLCHICINE AND COVID-19:
Colchicine For COVID-19:
https://www.youtube.com/watch?v=xGfD6BZFsNo

Resources used:
Canadian News article - https://thecanadian.news/2021/01/23/major-breakthrough-large-study-shows-effectiveness-of-colchicine-to-treat-covid-19/
ClinicalTrials.gov - https://clinicaltrials.gov/ct2/show/NCT04322682
Globenewswire article - https://www.globenewswire.com/news-release/2021/01/23/2163109/0/en/Colchicine-reduces-the-risk-of-COVID-19-related-complications.html
https://www.colcorona.net
Medscape Dosing - https://reference.medscape.com/drug/colcrys-mitigare-colchicine-342812
Article with Figure - https://www.reumatologiaclinica.org/es-colchicine-a-potential-therapeutic-tool-avance-S1699258X20301078#imagen
Toxicity Summary - https://pubmed.ncbi.nlm.nih.gov/20586571/
Greek Reported Article - https://greece.greekreporter.com/2021/01/24/greece-approves-drug-colchicine-in-the-fight-against-covid/

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There will be a running series of videos using the most up to date information on COVID-19, but this is an evolving field and new videos may come out that contradict that previous information. That is okay and is the nature of a fast paced and evolving clinical scenario. Stick with us as we work to unveil the intricacies of COVID-19, it's clinical significance, and the societal implications. ***This is strictly educational and not to be mistaken as clinical recommendations, please verify all information with accepted guidelines and practice patterns.***

DISCLAIMER
THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.


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