WhiteBoard style discussion on a newer theory that is gaining attention on the bradykinin pathway and how it may contribute to the respiratory failure seen with COVID-19. This pathway involves a bradykinin metabolite that typically is degraded by ACE2. When SARS-CoV-2 infects cells using the ACE2R, ACE2 is down regulated. As such, there is less of it available to convert the bradykinin metabolite DABK to it's more benign form. DABK then leads to inflammation, vascular permeability, and vasodilation that contributes to pulmonary alveolar fluid build up, impaired gas exchange, and inflammatory changes in the lungs. It also stimulates more production of bradykinin! Check out this video to understand how this may work. In this video, we will discuss this mechanism as it relates to COVID using various depictions. We will also discuss how the discovery of this pathway may lead to the identification of new therapeutic targets!
PLAYLIST ON COVID-19 PATHOPHYSIOLOGY:
https://youtube.com/playlist?list=PLf5bMa9_tvRiAsl2GNnLYM1zJZ8GNG_W_
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Articles used in preparing for this video:
(1) https://pubmed.ncbi.nlm.nih.gov/28935640/
(2) https://www.ncbi.nlm.nih.gov/books/NBK537187/
(3) https://asippathways.com/wp-content/uploads/2020/06/A-hypothesized-role-for-dysregulated-bradykinin-signaling-in-COVID-19_Roche_Published-Version.pdf
(4) https://www.the-scientist.com/news-opinion/is-a-bradykinin-storm-brewing-in-covid-19--67876
Links to previous videos related to the topic. CHECK THEM OUT!
Angiotensin II and COVID-19:
https://www.youtube.com/watch?v=m7MnwJvfpxQ&t=201s
COVID-19 and ARDS, The Syndrome That Is Killing People:
https://www.youtube.com/watch?v=rrHn4SzUl1U&t=23s
There will be a running series of videos using the most up to date information on COVID-19, but this is an evolving field and new videos may come out that contradict that previous information. That is okay and is the nature of a fast paced and evolving clinical scenario. Stick with us as we work to unveil the intricacies of COVID-19, it's clinical significance, and the societal implications. ***This is strictly educational and not to be mistaken as clinical recommendations, please verify all information with accepted guidelines and practice patterns.***
DISCLAIMER
THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.
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